Figure 5.

Heightened Fas-mediated killing of patients’ CD59⁺CD34⁺ cells in culture. (a) Separated PNH CD59^–CD34⁺ and CD59⁺CD34⁺ cells and normal CD59⁺CD34⁺ cells from cytopheresis samples of patient C and a healthy control were grown in culture as in Figure 2 in medium alone or medium containing agonist or antagonist mAb to CD95. The results represent the mean of six replicate experiments. (b) An identical experiment was done with separated cell populations from marrow samples of patient B and a corresponding control.