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. 2000 Sep 1;106(5):663–670. doi: 10.1172/JCI9362

Figure 3.

Figure 3

Multiple UV exposures cause sustained reduction of type I and type III procollagen proteins in human skin in vivo. Human skin was exposed to one, two, three, or four doses of UV (1 MED) at 24-hour intervals. Skin biopsies were obtained 24 hours after each exposure. Skin samples were analyzed for type I(α1) and type III(α1) procollagen and pN collagen protein levels using Western blot method. (a) Type I procollagen (open circle, solid line) and type I pN collagen (filled circle, broken line) protein in human skin. Inset shows representative Western blot. n = 7 subjects. (b) Type III procollagen (open circle, solid line) and type III pN collagen (filled circle, broken line) protein in human skin. Inset shows representative Western blot. n = 6 subjects. AP < 0.05 vs. no UV exposure.