FIGURE 3.

Aberrant intrinsic functional connectivity between DMN, SN, and CEN (inter-iFC) of patients. (A) Inter-iFC between two networks is based on Pearson’s correlation between network time courses. In healthy controls (HC), black lines indicate significant inter-iFC (one-sample t-tests, p < 0.05, Bonferroni-corrected for 15 correlations). Thickness of lines reflects absolute values of Fisher-z-normalized correlation coefficients. In patients with BPD, red lines indicate increased inter-iFC compared to healthy controls, while missing lines indicate significantly reduced and absent connections in BPD (two-sample t-tests, p < 0.05, Bonferroni-corrected). See also Table 5 for correlation coefficients of significant inter-iFC. Results are controlled for antipsychotic medication. (B) For each subject, the ratio (r) of overall inter-iFC for CEN and SN within the intrinsic functional architecture of DMN, SN, and CEN was calculated by r = inter-iFC_sum(CEN)/inter-iFC_sum(SN), with inter-iFC_sum for CEN and SN, respectively, reflecting summarized absolute z-values of inter-iFC. We found significantly reduced r in patients (two-sample t-test, **p = 0.007).