Table 2.
Genomic loci (coordinates) of UC associated CpG candidates where disease specific DNA methylation occurred according to the Illumina arrays from the pediatric cohort (loci meeting criteria for >4% mean methylation difference between UC and control: C; and Benjamini-Hochberg FDR<0.2). Numbers represent percent methylation. Gene associations are based on the Infinium HumanMethylation450 v1.1 manifest supplied by Illumina.
| Coordinates | Associated gene | C | UC | UC-C | FDR |
|---|---|---|---|---|---|
| chr13:20771319-20771319 | 56.19 | 27.33 | −28.86 | 0.07 | |
| chr20:60915009-60915009 | LAMA5 | 65.17 | 51.74 | −13.43 | 0.16 |
| chr6:31803832-31803832 | C6orf48,SNORD52 | 41.81 | 46.46 | 4.65 | 0.08 |
| chr2:34719565-34719565 | 68.06 | 73.05 | 4.99 | 0.19 | |
| chr1:44466601-44466601 | SLC6A9 | 75.83 | 81.34 | 5.51 | 0.16 |
| chr10:126360669-126360669 | FAM53B | 42.40 | 55.00 | 12.60 | 0.07 |