Table 2.
Comparison of CPC and MP Subsets Between DM and HC Groups
| Diabetics Median (IQR) | Controls Median (IQR) | Number of bins in the subset |
Pa | Adjusted ratiob (95% Cl) |
|
|---|---|---|---|---|---|
| Circulating progenitor cells | |||||
| CHSPCAng-Absc | 97 (61, 170) | 165 (100, 250) | 1 | 0.005 | 0.85 (0.63, 1.2) |
| CHSPCAng-Reld | 6.1 (4.0, 9.9) | 12 (7.5, 18) | 1 | <0.001 | 0.65 (0.49, 0.88) |
| Microparticle relative densitye | |||||
| CD31+/CD41a+ Bright | 5.4 ×10−3 (2.9 × 10−3, 1.1 ×10−2 | 1.5 × 10−2 (6.7 × 10−3, 2.8 ×10−2 | 168 | <0.001 | 0.31 (0.20, 0.51) |
| CD31+/CD41a+ Dim | 5.3 × 10−2 (3.7 × 10−2, 7.6 ×10−2 | 2.8 × 10−2 (1.8 × 10−2, 4.8 ×10−2 | 254 | <0.001 | 2.0 (1.4, 2.7) |
| Ratio of CD31+/CD41a+ | 11 (3.1, 21) | 2.1 (0.72, 4.2) | <0.001 | 6.5 (3.5, 12) | |
| Dim to Bright | |||||
| Annexin+ | 1.6 × 10−3 (9.1 × 10−4, 3.4 ×10−3) | 6.6 × 10−4(4.5 × 10−4, 1.2 ×10−3) | 7 | <0.001 | 2.1 (1.5, 3.1) |
| CD31+ | 3.7 × 10−3 (2.8 × 10−3, 6.0 ×10−3) | 2.0 × 10−3 (9.7 × 10−4, 4.0 ×10−3) | 20 | 0.001 | 2.2 (1.6, 3.2) |
| CD41a+ | 1.3 × 10−4(7.8 × 10−5, 3.2 ×10−4) | 5.7 × 10−5(2.6 × 10−5, 1.5 ×10−4) | 1 | 0.003 | 2.7 (1.7, 4.3) |
| Annexin+/CD31+/CD41a+ | 1.9 × 10−3 (8.6 × 10−4, 3.2 ×10−3) | 8.3 × 10−4(5.0 × 10−4, 1.5 ×10−3) | 8 | <0.001 | 2.2 (1.5, 3.3) |
| CD3+ | 1.2 × 10−3 (4.6 × 10−4, 2.1 ×10−3) | 3.6 × 10−4(9.9 × 10−5, 7.7 ×10−4) | 3 | <0.001 | 5.4 (2.7, 11) |
| CD105+ | 8.7 × 10−4(4.8 × 10−4, 1.2 ×10−3) | 4.0 × 10−4(1.3 × 10−4, 6.6 ×10−4) | 3 | <0.001 | 3.0 (1.9, 4.6) |
IQR, inter-quartile range.
a
Unadjusted P-values obtained from Wilcoxon rank-sum tests.
b
Obtained from multivariable linear regression models for log-transformed counts as discussed in the text.
c
CHSPCAng-Abs indicates a subset of CD31+/CD34+/CD45Dim to neg/CD133+ progenitor cells per mL of blood.
d
CHSPCAng-Rel indicates a subset of CD31+/CD34+/CD45Dim to neg/CD133+ progenitor cells as a percentage of events in the lymphocyte region of FSC-A vs. SSC-A.
e
Fraction of microparticles in the region of interest.