Table 1. ELISA IC₅₀ values, obtained by competition against sCD4 on gp120SF162 and gp120CN54, of the miniCD4s belonging to the M48 series.

NO		R	gp120SF162 IC50 (nM ± SEM)	gp120CN54 IC50 (nM ± SEM)	A: gp120SF162 $\frac{{\text{IC}}_{50}\text{M}48\text{Ux}}{{\text{IC}}_{50}\text{M}48}$	B: gp120SF162 $\frac{{\text{IC}}_{50}\text{M}48\text{Ux}}{{\text{IC}}_{50}\text{M}48}$	$\frac{{\text{IC}}_{50\text{CN}54}}{{\text{IC}}_{50\text{CN}54}}$	B/A
1	M48c		0.52 ± 0.04	1.9 ± 0.1	1	1	4	1
2	M48U1c		0.35 ± 0.07	0.37 ± 0.04	0.7	0.13	1	0.2
3	M48U2c		0.50 ± 0.09	1.7 ± 0.3	0.9	0.59	3	0.7
4	M48U3c		0.32 ± 0.06	11.7 ± 0.1	0.6	4.0	37	6.7
5	M48U4*		1.13 ± 0.18	6.6 ± 1	2.1	2.3	6	1.1
6	M48U5*		5.17 ± 1.26	50.2 ± 5.7	9.8	17	10	1.7
7	M48U6*		0.86 ± 0.07	10.1 ± 1.6	1.6	3.5	12	2.2
8	M48U7*		0.30 ± 0.06	2.4 ± 0.4	0.6	0.83	8	1.4
9	M48U8*		0.28 ± 0.05	3.4 ± 1.1	0.5	1.2	12	2.4
10	M48U9*		5.28 ± 0.46	38.2 ± 4.6	10	13	7	1.3
11	M48U10*		284 ± 21	13076 ± 415a	536	4509	46	8.4
12	M48U11*		2026 ± 277	12061 ± 27a	3823	4159	6	1.1
13	M48U12*		0.26 ± 0.05	0.31 ± 0.05	0.5	0.11	1	0.2
14	M48U13b,c		1.40 ± 0.46	15.5 ± 1.1	2.6	5.3	11	2
15	M48U14*		8.1 ± 1.6	1230 ± 180	15	424	152	28

^aExtrapolated values (maximum concentration tested was 10 mM).

^bEarlier called CD4M47¹⁵ or M47¹⁹

^cMentioned in reference (19).

^*New compounds. IC₅₀ values are presented as the mean ± SEM values from three independent experiments.