Fig. 3. Modulation of tumor cell proliferation by cytokines and ECM. 393T5 growth within microtissues (initial 17.4±3.4 cells per gel) when (A) cultured in media containing 50 μg ml–1 VEGF, HGF, EGF, or TGF-β, or (B) encapsulated in the presence of to 20 μg ml–1 of laminin, fibronectin, or collagen-1 that remain physically entrapped within the hydrogel scaffold. Average number of cells per gel calculated from microtissue fluorescence using linear regression. * indicates p < 0.01.
