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. 2013 Oct 28;203(2):251–264. doi: 10.1083/jcb.201303013

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© 2013 Lázaro-Diéguez et al.

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Figure 4. — Lateral lumen architecture contributes to but is not the sole reason for the mitotic spindle tilt. (A) Control and MDCK-Par1b cells were fixed and stained for gp135, α-tubulin, and chromatin (not depicted). The β angle was calculated in polarized control cells (gray bar) and cells expressing Par1b without defined lumen (“Non polarized”; BC-Ø, absence of lateral lumen) or with lateral lumen (AD-O and BD-O). In AD-O cells one spindle pole faced the lumen, whereas in BD-O cells none of the spindle poles oriented toward the lumen. Error bars indicate ± SD. ***, P ≤ 0.001. (B) Correlation between β and α angles in MDCK-Par1b (n = 114), WIF-B9 (n = 115), and HepG2 (n = 98) cells with hepatocyte polarity.