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Adaxonal localization of MVBs and uptake of oligodendroglial exosomes by neurons. (A) Electron micrograph of myelinated axons in the optic nerve labeled with antibodies against PLP (scale bar 200 nm, courtesy of Wiebke Möbius). (B) Confocal stack of primary cortical neurons (red) that internalized exosomes, labeled with PLP-EGFP and SIRT2-EYFP (green). Nuclei are blue, scale bar 20 μm.
