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. Author manuscript; available in PMC: 2014 Aug 29.
Published in final edited form as: Neuroscience. 2013 May 7;246:10.1016/j.neuroscience.2013.04.058. doi: 10.1016/j.neuroscience.2013.04.058

Figure 3. Minocycline treated adult Fmr1 KO mice demonstrated reduced hyperactivity and tendency to travel to the center of an open field, but these effects were not maintained 4 wks post-treatment.

Figure 3

(A–F) Graphs demonstrate the performance of adult Fmr1 KO mice in the open field as measured by the number of center entries (A, B), the total line crosses (C, D) and the percent time spent in thigmotaxis (E, F). WT and Fmr1 KO mice were tested immediately after 4 or 8 wks of treatment (A, C). All mice were tested again 4 wks after the treatment was stopped (4+4 wks or 8+4 wks, B, D). Vertical bars indicate SEM (n = 15 WT H2O, 19 Fmr1 KO H2O, 14 WT Mino, 14 Fmr1 KO Mino mice; *, p<0.05; **, p<0.01; ***, p<0.001).