Table 2.
Effect of EPG on hematological parameters of EAC-bearing mice
| Design of treatment | Normal | Tumor control |
EPG
(100 mg/Kg) |
EPG
(200 mg/Kg) |
EPG
(400 mg/Kg) |
|
|---|---|---|---|---|---|---|
| Hb (gm %) | 16.33 ± 1.1 | 5.9 ± 0.26 | 10.3 ± 1.64 | 11.5 ± 0.72 | 14.4 ± 0.21* | |
| RBC (106 cells/mm3) | 4.4 ± 0.2 | 2.7 ± 0.76 | 0.97 ± 3.7 | 4.05 ± 1.16 | 3.86 ± 0.21* | |
| WBC (103 cells/mm3) | 6.5 ± 0.1 | 13.7 ± 1.72 | 9.4 ± 1.3 | 8.1 ± 1.1 | 9.42 ± 0.1* | |
| Protein (mg %) | 8.5 ± 0.22 | 12.4 ± 1.7 | 9.8 ± 1.1*** | 8.12 ± 0.9 | 8.33 ± 0.3** | |
| PCV (mm) | 16.6 ± 0.21 | 34.33 ± 2.45 | 29 ± 2.7* | 24 ± 2.16** | 17.3 ± 0.22** | |
| Differential Count (%) |
Lymphocytes | 70.7 ± 1.1 | 60 ± 3.92 | 76 ± 3.64* | 83 ± 4.74* | 65.5 ± 0.21* |
| Neutrophils | 30.3 ± 0.21 | 38 ± 3.2 | 23 ± 1.36** | 15 ± 1.82 | 27.8 ± 0.25* | |
| Monocytes | 1 ± 0 | 1 ± 0 | 1 ± 0 | 2 ± 0 | 1 ± 0 | |
N = 5 animals in each group. Values are expressed as mean ± SEM.
* p < 0.001; **p < 0.01; ***p < 0.05 when compared with control. Data were analyzed by one-way ANOVA followed by Dunnett’s test.