Table 3.
Effect of drug : polymer ratio on drug loading efficiency, production yield and particle size of mefenamic acid microspheres
| Formulations | polymer : drug ratio | Production yield ) ٪ ± SD) | Theorical drug content ( ٪ ± SD) | Mean amount of drug entrapped ( ٪ ± SD) | Drug loading efficiency ( ٪ ± SD) | Mean particle size (μm ± SD) |
|---|---|---|---|---|---|---|
| F 1 | 0.75 : 1 | 94 ± 2.31 | 57.14 | 39.37 ± 4.11 | 68.9 ± 2.02 | 235.58 ±1.52 |
| F 2 | 1 : 1 | 92 ± 2.68 | 50 | 36.32 ± 3.25 | 72.64 ± 3.52 | 311.76 ± 1.72 |
| F 3 | 1.25 : 1 | 90 ± 3.79 | 44.44 | 43.22 ± 4.56 | 97.25 ± 3.65 | 436.41 ± 1.34 |
| F' 1 | 0.25 : 1 | 93 ± 3.56 | 80 | 60.96 ± 2.33 | 76.2 ± 5.61 | 358.84 ± 2.31 |
| F' 2 | 0.5 : 1 | 95 ± 4.71 | 66.66 | 42.14 ± 4.52 | 63.21 ± 4.85 | 407.93 ± 4.75 |
| F' 3 | 0.75 : 1 | 98 ± 3.41 | 57.14 | 37.56 ± 5.21 | 65.73 ± 3.98 | 442.10 ± 5.94 |
| Mix | 0.25 : 0.25 : 1 | 97.23 ± 0.24 | 66.67 | 68.74 ± 9.35 | 103.10 ± 5.69 | 298.28 ± 2.35 |
*F1 to F3 (microspheres containing CAP), F'1 to F'3 (microspheres containing EC) and Mix (microspheres containing CAP and EC).