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. 2011 Summer;10(3):469–479.

Table 4.

The results of physicochemical tests conducted on series A,B,C,D,E and F ibuprofen ODT formulations (results are presented as mean ± standard deviation).

(min or sec, n = 6) Friability
(%, n = 1)		 Hardness
(KP, n = 10)		 Uniformity of weight
(mg, n = 20)		 Thickness
(mm, n = 10)		 Appearance
(n = 10)		 Flowability (n = 3) Formulation
― ― ― ― ― ― Very poor F1
15.1±1.8 sec Not-acceptable 0.30±0.11 546.40±52.30 3.02±0.61 Undesirable Very poor F2
30.0±2.6 min Not-acceptable 0.50±0.09 602.60±55.22 3.51±0.55 Undesirable Very poor F3
30.0±2.6 min Not-acceptable 0.71±0.14 606.04±54.82 3.34±0.68 Undesirable Between very poor and poor F4
30.2±2.4 min Not-acceptable 1.30±0.07 599.01±38.19 3.11±0.40 Undesirable Moderate F5
30.7±2.6 min Not-acceptable 0.81±0.15 605.23±55.87 3.27±0.59 Undesirable Poor F6
― ― ― ― ― ― ― F7
― ― ― ― ― ― ― F8
― ― ― ― ― ― ― F9
8.3±2.4 min Not-acceptable 0.50±0.11 599.23±0.48 3.64±0.27 Desirable Between good and excellent F10
11.9±2.4 min Not-acceptable 0.40±0.08 603.04±0.51 3.65±0.28 Desirable Between good and excellent F11
7.0±2.5 min Not-acceptable 0.40±0.15 601.09±0.50 3.73±0.33 Desirable Between good and excellent F12
30.6±1.2 sec Not-acceptable 0.40±0.20 602.65±0.64 3.83±0.37 Desirable Between good and excellent F13
4.8±1.5 sec Not-acceptable 0.71±0.19 602.71±0.63 3.81±0.36 Desirable Between good and excellent F14
50.8±1.3 sec Not-acceptable 0.45±0.19 598.77±0.22 3.72±0.39 Desirable Excellent F15
4.6±3.1 sec Not-acceptable 0.81±0.11 602.14±0.09 3.71±0.28 Desirable Excellent F16
5.1±2.9 sec Not-acceptable 2.03±0.08 601.29±0.02 3.83±0.21 Desirable Excellent F17
56.4±3.1 sec Not-acceptable 0.95±0.13 602.65±0.07 3.80±0.32 Desirable Excellent F18
45.7±1.2 sec Notacceptable 0.70±0.14 604.01±0.04 3.82±0.35 Undesirable Excellent F19
54.7±1.1 sec Not-acceptable 1.22±0.15 779.01±0.18 4.48±0.25 Desirable Between good and excellent F17a
6.2±3.5 sec Not-acceptable 0.71±0.11 781.60±0.11 4.52±0.28 Desirable Excellent F17b
6.1±2.7 sec Not-acceptable 0.71±0.13 602.47±0.11 3.84±0.29 Desirable Excellent F20
49.8±1.3 sec Not-acceptable 1.05±0.14 780.35±0.16 4.45±0.24 Desirable Between good and excellent F20a
51.7±1.1 sec Not-acceptable 1.63±0.17 250.54±0.08 2.01±0.25 Desirable Excellent F21
6.2±3.0 sec Not-acceptable 1.87±0.21 502.13±0.13 3.85±0.31 Desirable Between good and excellent F21a
58.1±0.9 sec 0.48 3.20±0.16 135.71±0.15 2.24±0.18 Desirable Good F22
4.4±2.7 sec 0.34 3.50±0.19 271.42±1.86 3.50±0.24 Desirable Between poor and moderate F22a
46.2±1.1 sec 0.45 3.24±0.17 225.02±0.15 3.10±0.25 Desirable Between good and excellent F22s