Table 1.
Patients’ characteristics
| Characteristics | Whole patients (n = 41) | Patients with ototoxicity (n = 29) |
|---|---|---|
| Age (years) | (15-74) 38.29 ± 17.05 | (15-74) 41.13 ± 18.13 |
| Sex (F/M) | 21/20 | 11/18 |
| Weight (Kg) | (34-80) 49.13 ± 10.10 | (34-80) 49.45 ± 11.54 |
| BMI (Kg/m²) | (12-34) 19.2 ± 4.06 | (12-34) 18.95 ± 5.02 |
| Nationality (Afghani/Iranian) | 20/21 | 17/12 |
| Duration of treatment with amikacin (days) | (13-131) 45.07 ± 27.67 | (13-102) 35.97 ± 19.55 |
| Cigarette smoking | 9 | 8 |
| Drug abuse | 7 | 6 |
| Alcohol consumption | 3 | 3 |
| History of the pervious ototoxicity | 19 | 17 |
| Concomitant medications (in/de) | 32/9 | 23/6 |
| Renal impairment | 1 | 1 |
| Liver impairment | 9 | 7 |
F: Female; M: Male; Concomitant medications, in: Increase the amikacin blood concentrations (e.g. NSAIDS); Concomitant medications, de: Decrease the amikacin blood concentrations (e.g. Penicillins); Data about the history of ototoxicity was obtained by patients’ interview at the beginning of study