Table 2.
The relationship between the risk factors and the incidence of ototoxicity
| Factors | Test | p-value |
|---|---|---|
| Age (years) | Mann-Whitney | 0.2 |
| Sex (F/M) | Chi-square | 0.008 |
| Weight (Kg) | Mann-Whitney | 0.96 |
| BMI (Kg/m²) | Mann-Whitney | 1 |
| Nationality (Afghanian/Iranian) | Chi-square | 0.14 |
| History of Ototoxicity | Chi-square | 0.014 |
| Concomitant medications (in/de) | Fisher´s Exact test | 1 |
| Drug abuse | Fisher ´s Exact test | 0.65 |
| Cigarette smoking | Fisher´s Exact test | 0.24 |
| Renal impairment | Chi-square | 0.85 |
| Liver impairment | Fisher´s Exact test | 0.45 |
F: Female; M: Male; BMI: Body Mass Index; in: Increase the amikacin blood concentrations (e.g. NSAIDS); de: Decrease the amikacin blood concentrations (e.g. Penicillins