Table 3.
Effect of oral administration of aqueous extract of S. henningsii on plasma glucose level of STZ-induced diabetic rats
| Treatment |
Plasma blood glucose (mmol/L)
|
|||
|---|---|---|---|---|
| 0 (day) | 5 (day) | 10 (day) | 15 (day) | |
| Normal control | 5.60 ± 0.40 | 5.40 ± 0.53 | 5.6 ± 0.30 | 5.70 ± 0.32 |
| Diabetic control | 18.20 ± 0.30a | 23.45 ± 0.35a | 28.30 ± 0.40a | 30.10 ± 0.40a |
| Diabetic + SH (125 mg/kg) | 19.33 ± 1.20a | 16.35 ± 1.14b | 15.53 ± 1.30b | 12.56 ± 0.90b |
| Diabetic + SH (250 mg/kg) | 24.30 ± 0.09b | 22.20 ± 0.08 | 17.57 ± 1.02c | 14.27 ± 1.20c |
| Diabetic + SH (500 mg/kg) | 25.30 ± 0.01b | 20.20 ± 0.04c | 19.28 ± 0.10d | 17.70 ± 0.30d |
| Diabetic + glibenclamide (0.6 mg/kg) | 22.50 ± 3.30 c | 19.30 ± 3.20c | 17.78 ± 2.40c | 13.52 ± 2.50c |
Values are mean ± SD of 6 rats in each group. a-e Test values carrying superscripts different from the control for each parameter are significantly different (p < 0.05). Difference in blood glucose of each group (final-initial values): Diabetic (↑11.9 mmol/L); 125mg/Kg (↓6.7); 250 mg/Kg (↓10.03 mmol/L); 500 mg/Kg (↓7.60); Glibenclamide (↓8.98 mmol/L). Where ↑ means increase and ↓ represents decrease.