Table 1.

Spirometric parameters of subjects before and after treatment

Patient	Before treatment				After treatment			group	change in methacholine solution*
	FEV1 (%)	PC20 (mg/ml)	AR category	FEV1 (%)		PC20 (mg/ml)	AR category
1	98	4	borderline	93		1	mild	Placebo	-2
2	90	8	borderline	90		16	normal	Placebo	1
3	92	0.25	moderate to severe	88		0.125	moderate to severe	Drug	-1
4	112	8	borderline	109		2	mild	Drug	-2
5	103	4	borderline	104		4	borderline	Placebo	0
6	76	1	mild	77		1	mild	Drug	0
7	103	0.5	moderate to severe	98		16	normal	Drug	5
8	84	4	borderline	80		0.5	moderate to severe	Placebo	-3
9	78	4	borderline	78		2	mild	Placebo	-1
10	110	4	borderline	110		4	mild	Placebo	0
11	88	2	mild	89		0.25	moderate to severe	Placebo	-3
12	109	1	mild	88		2	mild	Placebo	1
13	90	2	mild	91		4	borderline	Drug	1
14	93	1	mild	94		1	mild	Placebo	0
15	116	1	mild	119		1	mild	Placebo	0
16	78	0.25	moderate to severe	86		1	mild	Drug	2
17	81	1	mild	93		16	normal	Drug	4
18	102	4	borderline	100		8	borderline	Drug	2
19	109	8	borderline	103		8	borderline	Drug	0
20	117	0.5	moderate to severe	110		0.5	moderate to severe	Placebo	0
21	90	0.5	moderate to severe	90		8	borderline	Placebo	4
22	82	2	mild	90		0.25	moderate to severe	Placebo	-3

AR: Airway responsiveness* Increase or decrease in solution concentration which caused more than 20% decrease in FEV1