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. 2012 Summer;11(3):733–745.

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© 2012 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Representative photographs of histological appearance of rat colonic mucosa. A= Normal control group, B= Colitis control group, after exposure to TNBS (100 mg/kg) the colon is markedly inflamed, the mucosal wall is thickened, and there is a transmural inflammatory cell infiltration. C= Budesonide pectin/Surelease coated pellet (300 μg/kg/day) group, D= Budesonide solution group (300 μg/kg/day), E=Budesonide uncoated pellet group (300 μg/kg/day), F= Placebo pellet group, G= Mesalazine enema (400 mg / kg/day, rectally) group, H= Budesonide enema (20 mcg/kg/day, rectally) group and I= Prednisolone (5 mg /kg /day, oral) group. Hematoxylin and eosin stain with original magnification 10×.