Table 2.
Effect of VFE on serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in Alloxan-diabetic rats, after 21 days of treatment
| Groups | Dose (mg/Kg bw) |
Serum lipids (mg/dL)
|
||||
|---|---|---|---|---|---|---|
| TG | TC | HDL | LDL | VLDL | ||
| NC | - | 85.2 ± 4.8 a | 79.5 ± 4.8 a | 39.2 ± 5.1 a | 21.2 ± 5.6 a | 15.3 ± 2.4 a |
| DC | - | 147.6 ± 7.1 | 118.3 ± 7.8 | 28.6 ± 5.6 | 46.9 ± 11.4 | 26.3 ± 2.1 |
| ASE+D | 500 | 115.4 ± 6.4 b | 77 ± 6.2 a | 31.4 ± 3.7 e | 39.3 ± 7.2 c | 23.61 ± 2.7 e |
| AAE+D | 500 | 95.3 ± 4.6 a | 91.3 ± 4.7 b | 29.5 ± 5.4 e | 33.6 ± 3.8 b | 19.8 ± 1.32 b |
| SOE+D | 250 | 87.33 ± 3.7 a | 89.33 ± 5 b | 29.6 ± 2.08 e | 32.67 ± 3.51 b | 20.33 ± 1.54 b |
| Met+D | 100 | 129.4 ± 5.3 c | 106.7 ± 7.7 e | 27.1 ± 6.2 e | 42.5 ± 8.9 e | 24.6 ± 1.3 e |
NC: normal control, DC: diabetic control, ASE+D: diabetic rats treated with 500 mg Kg−1 BW of Allium sativum bulbs methanolic extracts, AAE+D: diabetic rats treated with 500 mg Kg−1 BW of Allium ascalonicum bulbs methanolic extracts, SOE+D: diabetic rats treated with 250 mg Kg−1 BW of Salvia officinalis leaves methanolic extracts respectively, Met+D: Diabetic rats treated with metformin. Each value is.the mean ± SD of ten separate experiments. a p < 0.0001 vs. DC. b p < 0.001 vs. DC. c p < 0.043 vs. DC. e p > 0.156 vs. DC