Table 1.
Effect of methanol extract of Otostegia persica on plasma transaminase enzyme levels against the CCl4-induced liver damage
| Materials |
Dose
(mg/kg) |
ALT
IU/L (mean ± S.E.M) |
% change a |
AST
IU/L (mean ± S.E.M) |
% change a | |
|---|---|---|---|---|---|---|
| Control | 99.5 ± 3.8 | - | 165 ± 12.8 | - | ||
| CCl4b | 2.5c | 3290 ± 215.8*** | + 3206.53 | 4392 ± 129.5*** | + 2561.82 | |
| Legalond | 420 | 1434 ± 178.5*** | – 56.41 | 2533 ± 178.5*** | – 42.33 | |
| Extractd | 200 | 3035 ± 122.3 | – 7.75 | 4119 ± 191.6 | – 6.21 | |
| 300 | 2140 ± 249.2** | – 34.95 | 2996 ± 104.5*** | – 31.78 | ||
| 400 | 2857 ± 149.5 | – 13.16 | 3883 ± 49 | – 11.59 | ||
a (+) represents percentage of increase and (–) represents decrease in each value compared with either control or CCl4. b Compared with control. c The dose unit is mL/kg. d Compared with CCl4 as hepatotoxin. ** p < 0.01 significant from control or CCl4. *** p < 0.001 significant from control or CCl4