Table 2.
Effect of methanol extract of Otostegia persica on plasma and liver MDA and liver GSH against the CCl4-induced liver damage
| Material |
Dose
(mg/kg) |
Plasma MDA level
nmol/mL plasma |
% change a |
Liver MDA level
nmol/g liver |
% change a |
Liver GSH level
μmol/g liver |
% change |
|---|---|---|---|---|---|---|---|
| Control | - | 0.673 ± 0.02 | - | 313 ± 17.4 | - | 114.32 ± 5.17 | - |
| CCl4b | 2.5c | 3 ± 0.07*** | + 345. 77 | 679.86 ± 14.9*** | + 117.21 | 55.45 ± 3.7*** | – 51.5 |
| Legalond | 420 | 1.9 ± 0.35** | – 36.67 | 445.26 ± 34.4** | – 34.5 | 91.63 ± 6.56*** | + 65.2 |
| Extractd | 200 | 2.9 ± 0.07 | – 3.3 | 627.4 ± 44.9 | – 7.72 | 62.47 ± 2.38 | + 12.7 |
| 300 | 2.2 ± 0.24* | – 26.6 | 523.78 ± 31.5* | – 22.96 | 84.55 ± 7.2** | + 52.5 | |
| 400 | 2.8 ± 0.03 | – 6.66 | 602.03 ± 52.1 | – 11.45 | 67.06 ± 3.85 | + 20.9 |
Results are expressed as mean ± SEM. a (+) represents the percentage of increase and (-) represents the decrease in each value when compared with either control or CCl4. b Compared with control. cThe dose unit is mL/Kg. d Compared with CCl4 as hepatotoxin.*p < 0.05 significant from control or CCl4. **p < 0.01 significant from control or CCl4.*** p < 0.001 significant from control or CCl4