Table 3.

Histopathological changes in the liver of rats

Microscopic observation	Control	CCl4	Legalon	Extract 200 mg/kg	Extract 300 mg/kg	Extract 400 mg/kg
Degeneration in hepatocytes (fatty and hydropic changes)	Ø	+ + +	⊥	+ +	+	+ +
Degeneration in hepatic cords	Ø	+ +	+	+ +	+	+
Deformation in hepatocytes	Ø	+	⊥	+	+	+
Focal necrosis	Ø	+	Ø	⊥	Ø	Ø
Congestion in central vein	⊥	+ +	+	+ +	+	+ +
Congestion in sinusoids	Ø	+	+	+	+	+
Infiltration of lymphocytes	+	+ + +	+	+ + +	+	++
Kupffer cells proliferation	Ø	+	Ø	⊥	⊥	⊥
Bleeding area in hepatic lobes	Ø	Ø	Ø	Ø	Ø	Ø

Ø: absent; ⊥: minimal; +: mild; + +: moderate, + + +: severe