Table 1.
Effect of orally administration of safranal at doses 0.1, 0.25 and 0.5 mL/kg on hematological parameters in male Wistar rats treated for 21 consecutive days.
| Parameter | Control |
Safranal
0.1 mL/Kg |
Safranal
0.25 mL/Kg |
Safranal
0.5 mL/Kg |
|---|---|---|---|---|
| WBC (×103μL) | 6.13 ± 0.82 | 6.1 ± 0.37 | 7.6 ± 0.57 | 5.75 ± 0.94 |
| RBC (×106/μL) | 8.23 ± 0.17 | 7.5 ± 0.21* | 4.94 ± 0.19 *** | 3.7 ± 0.2 *** |
| Hemoglobin (g /dL) | 15.28 ± 0.23 | 13.18 ± 0.33 | 8.56 ± 0.33 | 6.05 ± 0.46 *** |
| Hematocrit (%) | 44.7 ± 1.02 | 37.86 ± 0.94 *** | 26.58 ± 0.72 *** | 22.66 ± 0.71 *** |
| MCV (fL) | 54.03 ± 0.53 | 50.5 ± 0.3 | 51.25 ± 1.51 | 51.85 ± 1.11 |
| MCH (pg) | 18.63 ± 0.22 | 17.61 ± 0.13 | 17.91 ± 0.37 | 18.06 ± 0.21 |
| MCHC (g/dL) | 34.53 ± 0.26 | 34.85 ± 0.11 | 34.06 ± 0.46 | 35.26 ± 0.3 |
| Platelets (×103 /μL) | 910 ± 41.36 | 689.33 ± 76.3 * | 269.16 ±38.78*** | 84.66 ± 11.56*** |
Data showed as mean ± SEM. (n = 6). ***p < 0.001, *p < 0.05, compared with control. Tukey–Kramer. RBC: red blood cell, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration and WBC: white blood cell.