Table 1.
Histo-pathological effects of the methanolic extract of Feijoa sellowiana fruit at different concentrations of 10, 20, 40, 50, 100 mg/kg.
|
Histopathological
Parameters |
Negative
Control (10mL/Kg) |
Feijoa sellowiana
(mg/kg)
10 20 40 50 100 (mg/kg) |
Positive
Control (5mg/kg) |
|---|---|---|---|
| Kupffer cells | + | +3 +3 +3 +2** +2** | + 3* |
| Edematous cells | + | +1 +1 +1 +2* +2** | +4* |
| Mononuclear cells | + | - +1 +1 +2 +2 | +2 |
| hemorrhage | _ | +1 +1 +1 +2* +3** | +4 |
| Necrosis | _ | - - +1 +2* +3** | + 5** |
-no effect, +1minor effect, +2medium effect, +3major effect, +4high effect, +5extra-high effect. *p < 0.05, **p < 0.01, significantly different from the control group using Fisher, exact test. Data are presented as means of three replicates