Table 2.
Effects of the pretreatment with Teucrium polium L. extract on the serum levels of direct and total bilirubin in acetaminophen-induced hepatotoxicity
| Groups | Direct bilirubin | Total bilirubin |
|---|---|---|
| 1. normal saline | .3100 ± 06437 | .4925 ± .12361 |
| 2. T. polium (500 mg/Kg) | .3438 ± .08450 | .5112 ±.14025 |
| 3. Acetaminophen (500 mg/Kg) | .4225 ± .08940 | .6075 ±.18211 |
| 4. T. polium 125 mg/Kg + Acetaminophen | .4488 ± .09658 | .5762 ±.13511 |
| 5. T. polium 250 mg/Kg + Acetaminophen | .3900 ± .10981 | .5925 ±.15360 |
| 6. T. polium 500 mg/Kg + Acetaminophen | .3712 ± .11319 | .5412 ±.15797 |
Animals in group 1 received normal saline solution, whereas animals in group 2 received T. polium L. extract (500 mg/Kg) for 5 days. Group 3 received acetaminophen on the fifth day. The mice in groups 4, 5 and 6 were pretreated with T. polium L. extract (125, 250 and 500 mg/Kg, po, respectively) once daily for five consecutive days. One hour after the final treatment, the mice were treated with acetaminophen (500 mg/Kg, po). Each value represents the mean ± SD for eight mice. a: Significantly different from the control (p < 0.05). b: Significantly different from acetaminophen group ( p < 0.05).