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. 2013 Winter;12(1):123–129.

Table 2.

Effects of the pretreatment with Teucrium polium L. extract on the serum levels of direct and total bilirubin in acetaminophen-induced hepatotoxicity

Groups Direct bilirubin Total bilirubin
1. normal saline .3100 ± 06437 .4925 ± .12361
2. T. polium (500 mg/Kg) .3438 ± .08450 .5112 ±.14025
3. Acetaminophen (500 mg/Kg) .4225 ± .08940 .6075 ±.18211
4. T. polium 125 mg/Kg + Acetaminophen .4488 ± .09658 .5762 ±.13511
5. T. polium 250 mg/Kg + Acetaminophen .3900 ± .10981 .5925 ±.15360
6. T. polium 500 mg/Kg + Acetaminophen .3712 ± .11319 .5412 ±.15797

Animals in group 1 received normal saline solution, whereas animals in group 2 received T. polium L. extract (500 mg/Kg) for 5 days. Group 3 received acetaminophen on the fifth day. The mice in groups 4, 5 and 6 were pretreated with T. polium L. extract (125, 250 and 500 mg/Kg, po, respectively) once daily for five consecutive days. One hour after the final treatment, the mice were treated with acetaminophen (500 mg/Kg, po). Each value represents the mean ± SD for eight mice. a: Significantly different from the control (p < 0.05). b: Significantly different from acetaminophen group ( p < 0.05).

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