Table 2.
Effect of glibenclamide and AEBI on body weight in normal and diabetic rats
| Group (n = 6) | Treatment | Dose (mg/Kg) | Average body weight (g) | |||
|---|---|---|---|---|---|---|
| Week 0 | Week 2 | Week 4 | Week 6 | |||
| 1 | N+C | 10 mL/Kg | 193.20 ± 6.58 | 211.56 ± 4.74 | 233.34 ± 3.20** | 247.62 ± 1.87** |
| 2 | N+AEBI | 250 | 204.08 ± 6.03 | 216.28 ± 5.22 | 226.90 ± 4.78 | 236.78 ± 3.58** |
| 3 | N+AEBI | 500 | 200.94 ± 3.47 | 210.20 ± 2.91 | 219.76 ± 3.34 | 236.86 ± 3.18** |
| 4 | N+G | 0.6 | 197.86 ± 6.20 | 212.32 ± 4.41 | 223.64 ± 4.02* | 238.80 ± 2.41** |
| 5 | D+C | 10 mL/Kg | 206.84 ± 3.35 | 155.28 ± 4.97#** | 144.90 ± 2.01#** | 137.98 ± 2.24#** |
| 6 | D+AEBI | 250 | 195.04 ± 4.67 | 183.44 ± 2.88d | 180.96 ± 3.74d | 187.56 ± 3.73d |
| 7 | D+AEBI | 500 | 194.36 ± 1.78 | 181.90 ± 1.62d | 183.52 ± 5.97d | 200.22 ± 2.78d |
| 8 | D+G | 0.6 | 199.94 ± 1.72 | 184.30 ± 4.08d | 193.46 ± 5.53d | 203.52 ± 5.61d |
AEBI: Aqueous extract of Berberis integerrima; N: normal; C: control; G: glibenclamide; D: diabetic; Values are presented as mean ± SEM. n = 6 in each group. One way ANOVA followed by Tukey test. a p < 0.05 and bp < 0.01 Normal treated rats were compared with Normal control rats. #p < 0.01 Diabetic control rats were compared with Normal control Rats. cp < 0.05 and dp < 0.01 Diabetic treated rats were compared with Diabetic control Rats on corresponding day;*p < 0.05 and**p < 0.01 compared to 0 value