Table 4.
Effect of glibenclamide and AEBI on the liver parameters (mg/dL) in normal and diabetic rats.
| Group (n = 6) | Treatment | Dose (mg/Kg) |
liver parameters (mg/dL) |
||||
|---|---|---|---|---|---|---|---|
| ALP | ALT | AST | T bilirubin | T protein | |||
| 1 | N+C | 10 mL/Kg | 93.82 ± 4.76 | 25.84 ± 1.60 | 21.00 ± 1.57 | 0.83 ± .04 | 2.06.08 |
| 2 | N+AEBI | 250 | 85.62 ± 4.15 | 23.28 ± 1.83 | 20.02 ± 099 | 0.74 ± .02 | 2.14 ± .22 |
| 3 | N+AEBI | 500 | 82.80 ± 1.59 | 21.10 ± 1.78 | 17.56 ± .99 | 0.76 ± .03 | 2.30 ± .23 |
| 4 | N+G | 0.6 | 84.06 ± 2.28 | 22.42 ± 2.08 | 19.10 ± .88 | 0.76 ± .03 | 2.17 ± .12 |
| 5 | D+C | 10 mL/Kg | 180.78 ± 3.25# | 48.92 ± 1.96# | 44.68 ± 2.35# | 1.39 ± .06# | 0.49 ± .05# |
| 6 | D+AEBI | 250 | 147.34 ± 4.56d | 36.06 ± 1.89d | 25.68 ± 1.79d | 1.03 ± .07d | 1.15 ± .05c |
| 7 | D+AEBI | 500 | 101.56 ± 7.79d | 24.28 ± 1.74d | 22.02 ± 1.56d | 0.82 ± .05d | 1.80 ± .10d |
| 8 | D+G | 0.6 | 112.94 ± 5.48d | 28.06 ± 1.48d | 22.20 ± .65d | 0.97 ± .09d | 1.12 ± .08c |
AEBI: Aqueous Extract of Berberis Integerrima; N: normal; C: control; G: glibenclamide; D: diabetic; Values are presented as mean ± SEM; n = 6 in each group. One way ANOVA followed by Tukey test. a p < 0.05 and bp < 0.01; Normal treated rats were compared with Normal control rats. #p < 0.01; Diabetic control rats were compared with Normal control rats. cp < 0.05 and dp < 0.01; Diabetic treated rats were compared with diabetic control rats