Table 2.

Pharmacokinetic differences of wogonoside after oral administration of pure baicalin (0.21 g/kg), Radix Scutellariae extract (0.46 g/kg) and Scutellariae-Paeoniae couple (1.16 g/kg) to normal and UC rats

Parameter	Unit	Normal-rats			UC- rats
		Pure baicalin	Radix scutellariae	Scutellariae- Paeoniae couple	Pure baicalin	Radix scutellariae	Scutellariae-Paeoniae couple
Cmax	μg/mL	1.23±0.12	1.79±0.23	4.12±0.15	4.42±0.26*	5.32±0.34*	10.06±0.94*
Tmax	h	0.11±0.1	0.22±0.09	0.21±0.08	0.12±0.08	0.14±0.09	0.15±0.1
AUC0-t	μg/mL·h	14.67±1.93	22.89±3.17	40.35±4.96	40.86±5.31*	57.95±1.91*	101.31±3.05*
T1/2	h	8.20±0.42	8.80±0.95	10.88±0.51	8.99±0.94	9.79±0.32	11.76±1.89
MRT	h	9.74±0.08	9.48±0.48	11.6±0.73	9.46±1.32	11.75±1.67	12.52±0.87

Mean ± S.D., n=10; *p<0.05 vs. normal-rats