Table 2.
Effects of ASE , AAE and SOE on oral glucose tolerance test in alloxan-diabetic rats. The plants extracts and the reference drug was administered to 16 h fasted rats, and 30 min later all groups received a carbohydrate solution (maltose and sucrose each 1 g/kg BW) by gastric intubations. Postprandial blood glucose was monitored at 0, 30, 60 and 120 min after carbohydrate solution administration
| Groups |
Dose
(mgkg −1 BW) |
Blood glucose (mg/dL)
|
|||
|---|---|---|---|---|---|
|
minute after a single dose administration of extracts and drug
| |||||
| 0 | 30 | 60 | 120 | ||
| NC | - | 70.32±3.2b | 139.23±7.3a,b | 119.38±5.1a,b | 87.76±4.3a,b |
| DC | - | 186.74±7.4 | 329.56±14.8a | 288.72±11.7a | 254.68±13.3a |
| ASEa+D | 250 | 189.72±15.5 | 295.41±9.1a,b | 261.8±7.9a,b | 225.72±10.3a,b |
| ASEb+D | 500 | 194.37±13.2 | 298.63±8.2a,b | 267.73±12.2a,b | 219.86±14.1a,b |
| AAEa+D | 250 | 192.25±10.1 | 289.92±13a,b | 270.43±8.2a,b | 231.3±11.6a,b |
| AAEb+D | 500 | 189.44±8.7 | 292.56±12.6a,b | 263.31±9.2a,b | 223.85±6.8a,b |
| SOEa+D | 250 | 173.8±13.7c | 271.82±14.2a,b | 194.42±12.5a,b,c | 220.4±11.7a,b |
| Ac+D | 20 | 161.43 ± 7.6b | 244.54 ± 10.8a,b | 183.34 ±7.6a,b | 165.82 ± 6.5b |
NC: normal control, DC: diabetic control, ASEa+D and ASEb+D: diabetic rats treated with 250 and 500 mg kg−1 BW of Allium sativum bulbs methanolic extracts respectively, AAEa+D and AAEb+D: diabetic rats treated with 250 and 500 mg kg−1 BW of Allium ascalonicum bulbs methanolic extracts respectively, SOEa+D: diabetic rats treated with 250 mg kg−1 BW of Salvia officinalis leaves methanolic extract, Ac+D: diabetic rats treated with acarbose. Each value is the mean ± SD. of ten separate experiments.a p < 0.05 vs. Time0, b p < 0.05 vs. DC, c p > 0.1 vs. Ac+D.