Table 1.
Baseline Characteristics | No. | % |
---|---|---|
Age at cohort enrollment, years | ||
22–39 | 21,237 | 18.0 |
40–49 | 32,363 | 27.4 |
50–59 | 30,207 | 25.6 |
60–69 | 20,681 | 17.5 |
70–79 | 13,676 | 11.6 |
Age at menarche, yearsb | ||
≤11 | 26,597 | 22.8 |
12 | 32,016 | 27.5 |
13 | 34,326 | 29.4 |
≥14 | 23,613 | 20.3 |
OC use | ||
Never used | 35,596 | 31.3 |
Former user at baseline | 6,659 | 5.9 |
Current user at baseline | 71,220 | 62.6 |
Ever used, unknown if current or former | 256 | 0.2 |
Duration of OC use, yearsc | ||
<1 | 8,947 | 11.8 |
1–4 | 26,355 | 34.7 |
5–9 | 24,076 | 31.7 |
≥10 | 16,488 | 21.7 |
Parity | ||
Nulligravid | 23,906 | 20.6 |
Gravid, nulliparous | 7,124 | 6.1 |
1–2 full-term pregnancies | 56,306 | 48.5 |
≥3 full-term pregnancies | 28,721 | 24.7 |
Age at first full-term pregnancy, yearsd | ||
≤19 | 4,479 | 5.3 |
20–24 | 26,629 | 31.3 |
25–29 | 34,541 | 40.6 |
30–34 | 14,782 | 17.4 |
≥35 | 4,595 | 5.4 |
Breastfeeding historye | ||
Never breastfed | 19,009 | 22.5 |
Ever breastfed | 65,796 | 77.5 |
Menopausal status/HT use | ||
Premenopausal | 47,993 | 43.5 |
Postmenopausal, never used HT | 13,956 | 12.7 |
Postmenopausal, ever used HTf | 46,922 | 43.1 |
HT usef,g | ||
Past HT user | 8,803 | 19.7 |
Current user of ET | 15,508 | 34.7 |
Current user of EPT | 20,334 | 45.5 |
Age at menopause, yearsh | ||
≤46 | 13,067 | 28.2 |
47–49 | 9,083 | 19.6 |
50–52 | 12,666 | 27.3 |
≥53 | 11,571 | 24.9 |
Body mass indexi | ||
<25 | 69,318 | 60.8 |
25 to <30 | 28,388 | 24.9 |
≥30 | 16,221 | 14.2 |
Smoking history | ||
Never | 77,619 | 65.7 |
Former | 33,779 | 28.6 |
Current | 6,084 | 5.2 |
History of diabetes | 3,298 | 2.8 |
Abbreviations: EPT, estrogen-plus-progestin therapy; ET, estrogen-only therapy; HT, hormone therapy; OC, oral contraceptive.
a Numbers shown do not include subjects with missing information on pregnancy history (n = 2,107), body mass index (n = 4,237), smoking status (n = 682), age at menarche (n = 1,558), OC use (n = 4,433), duration of OC use (n = 6,702), age at first full-term pregnancy (n = 1), breastfeeding (n = 1), menopausal status/HT use (n = 9,293), age at menopause (n = 18,886), and HT use (n = 1,297).
b Fifty-four participants who had never had a first menstrual period are not shown.
c Among OC users.
d Among parous participants.
e Among participants who ever had a live birth (n = 84,807).
f Excludes participants who used a progestin-only therapy (n = 980).
g Among ever HT users.
h Among postmenopausal participants.
i Weight (kg)/height (m)2.