Table 1.
Effect of 2-aryl-1,3-indandione derivatives at 0.5 mM concentration on in-vitro platelet aggregation induced by ADP.
| Compound |
ADP (5 μM)
|
|
|---|---|---|
| Aggregation a (%) | Inhibition (%) | |
| Control | 77.196 ± 5.49 | |
| Indomethacinb | 70.93 ± 4.53 | 8.11 |
| ASAb | 61.1 ± 1.23 | 21 |
| Quercetin | 75.6 ± 2.26 | 2 |
| 7 | 51.42 ± 4.6 | 33.39 |
| 15a | 50.28 ± 1.30 | 34.86 |
| 15b | 48.21 ± 1.58 | 37.54 |
| 8 | 49.03 ± 3.76 | 36.48 |
| 16a | 47.10 ± 0.87 | 38.98 |
| 16b | 44.9 ± 2.58 | 41.83 |
| 9 | 47.7 ± 3.46 | 38.20 |
| 17a | 49.1 ± 5.05 | 36.39 |
| 17b | NDc | ND |
| 10 | 44.01 ± 2.55 | 42.98 |
| 18a | 51.18 ± 1.75 | 33.70 |
| 18b | 48.38 ± 6.64 | 37.32 |
| 11 | 57.75 ± 4.26 | 25.19 |
| 19a | 45.12 ± 2.69 | 41.55 |
| 19b | 53.28 ± 3.01 | 30.98 |