Table 2.
Inhibitory effect of 2-aryl-1,3-indandione derivatives on in-vitro platelet aggregation induced by arachidonic acid (AA).
| Compound |
AA (1.35 mM)
|
||
|---|---|---|---|
| 500 (μM) | 250 (μM) | IC 50 (μM) | |
| ASAa | 95% | 95% | 0.24 |
| Quercetin | 36% | 1% | 353 |
| 7 | 0% | 0% | NDb |
| 15a | 100% | 100% | 196 |
| 15b | 100% | 100% | 136 |
| 8 | 0% | 0% | ND |
| 16a | 100% | 3% | 392 |
| 16b | 100% | 8% | 411 |
| 9 | 5% | 0% | ND |
| 17a | 16% | 16% | ND |
| 17b | ND | ND | ND |
| 10 | 0% | 0% | ND |
| 18a | 100% | 12% | 400 |
| 18b | 100% | 15% | 251 |
| 11 | 0% | 0% | ND |
| 19a | 100% | 50% | 243 |
| 19b | 100% | 10% | 429 |
a ASA (Acetylsalicylic acid) was used as a positive control. b ND = not determined