Table 1.
Comparison of tumor grade by local and central pathology review
| Central by Local Grade |
||||
|---|---|---|---|---|
| Tumor Grade by Local Pathology Review |
Total (n = 648) | |||
| Missing (n = 16) | Grade I (n = 47) | Grade II (n = 585) | ||
| n (%) | n (%) | n (%) | n (%) | |
| Tumor grade by central pathology review | ||||
| Missing | 2 (12.5) | 23 (48.9) | 195 (33.3) | 220 (34.0) |
| Grade II | 12 (75.0) | 19 (40.4) | 308 (52.6) | 339 (52.3) |
| HGG | 2 (12.5) | 2 (4.3) | 65 (11.1) | 69 (10.6) |
| Grade I | 0 (0.0) | 3 (6.4) | 6 (1.0) | 9 (1.4) |
| Other pathology | 0 (0.0) | 0 (0.0) | 11 (1.9) | 11 (1.7) |
In EORTC patients, 585 were locally diagnosed with grade II (WHO 1979); 390 were centrally reviewed (gray area). Grade II was confirmed in 308 patients. Of the 648 eligible patients, 339 were diagnosed with grade II by the central pathologist (black frame). These patients were considered for the prognostic factor analyses.