Table 4.
Comparison of outcomes between EORTC and RTOG/NCCTG data: all patients and by risk group
| PFS |
OS |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| N patients/n events | Median, mo (95% CI) | PFS3y (95% CI) | P | N/E | Median, mo (95% CI) | OS5y | P | ||
| All patients | EORTC | 339/235 | 55.33 (49.35, 63.38) | 67.96 (62.60, 72.73) | .01 | 339/183 | 86.54 (78.55, 99.19) | 65.92 (60.36, 70.90) | .025 |
| RTOG/NCCTG | 450/313 | 65.97 (55.13, 74.87) | 66.47 (61.86, 70.65) | 450/256 | 110.06 (95.87, 129.05) | 67.66 (63.06, 71.82) | |||
| Low risk | EORTC | 104/50 | 86.28 (74.28, 167.66) | 83.43 (74.38, 89.51) | .48 | 116/41 | 152.02 (101.72, N) | 76.88 (67.47, 83.89) | 0.92 |
| RTOG/NCCTG | 240/153 | 86.54 (69.62, 113.15) | 75.43 (69.41, 80.43) | 229/110 | 139.17 (120.97, 161.41) | 76.91 (70.76, 81.93) | |||
| Intermediate risk | EORTC | 115/77 | 56.48 (44.09, 70.60) | 71.18 (61.76, 78.67) | .53 | 106/56 | 90.71 (74.71, 106.97) | 72.18 (62.07, 80.02) | .67 |
| RTOG/NCCTG | 113/89 | 43.73 (37.39, 57.40) | 61.54 (51.85, 69.85) | 102/65 | 86.60 (62.26, 132.83) | 61.78 (51.46, 70.53) | |||
| High risk | EORTC | 119/108 | 39.33 (25.92, 42.32) | 51.85 (42.49, 60.41) | .34 | 116/86 | 57.72 (45.17, 75.27) | 49.90 (40.25, 58.79) | .55 |
| RTOG/NCCTG | 65/51 | 20.01 (9.99, 48.82) | 42.39 (30.20, 54.05) | 87/64 | 65.35 (31.57, 86.74) | 50.04 (39.09, 60.02) | |||
HRs were not included in any comparisons. They cannot be interpreted when curves are crossing over, which was the case for some of them.