Table 2. Blood gas analysis of line Umod A227T at the age of 9 months.
| Parameter | Males | Females | ||||
|---|---|---|---|---|---|---|
| Homozygous mutants | Heterozygous mutants | Wild-type controls | Homozygous mutants | Heterozygous mutants | Wild-type controls | |
| pH | 7.33 ± 0.01 | 7.34 ± 0.01 | 7.33 ± 0.01 | 7.35 ± 0.01 b | 7.31 ± 0.01 | 7.31 ± 0.01 |
| pCO2 (mm Hg) | 46.2 ± 1.0 | 45.0 ± 1.1 | 45.5 ± 1.8 | 42.6 ± 0.8 a | 45.1 ± 1.5 | 46.3 ± 1.5 |
| pO2 (mm Hg) | 48.8 ± 2.3 | 56.8 ± 5.5 | 63.8 ± 7.2 | 51.8 ± 1.9 a | 51.8 ± 2.2 | 57.2 ± 1.4 |
| sO2 (%) | 80.1 ± 2.2 a | 84.1 ± 2.8 | 87.4 ± 1.9 | 84.0 ± 1.7 | 82.3 ± 2.1 | 81.4 ± 5.0 |
| HCO3 - (mmol/l) | 23.9 ± 0.6 | 23.5 ± 0.6 | 22.3 ± 1.5 | 23.0 ± 0.5 | 22.2 ± 0.6 | 22.5 ± 0.7 |
| ABE (mmol/l) | -1.9 ± 0.7 | -2.1 ± 0.6 | -2.4 ± 0.5 | -2.0 ± 0.6 | -3.6 ± 0.6 | -3.4 ± 0.6 |
sO2, oxygen saturation; ABE, actual base excess.
No. per genotype and sex: n = 9-10. Data are presented as mean ± standard error of mean. Student’s t-test vs. wild-type controls: a P < 0.05, b P < 0.01.