Table 6. Cox proportional hazard regression models showing baseline IL-6 and sTNFR2 independently predicted incident cancers.
|
Model 1
|
Model 2
|
Model 3
|
Model 4
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
(Base Model b)
|
(Base Model + WC)
|
(Base Model + Diabetes)
|
(Base Model + WC +Diabetes)
|
||||||||
| Baseline parameters | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |||
| CRP, per mg/La | 1.20 (0.99-1.44) | 0.062 | 1.17 (0.96-1.42) | 0.124 | 1.19 (0.98-1.43) | 0.073 | 1.17 (0.96-1.42) | 0.127 | |||
| IL-6, per pg/mla | 1.51 (1.18-1.95) | 0.001 | 1.49 (1.15-1.91) | 0.002 | 1.52 (1.18-1.96) | 0.001 | 1.50 (1.16-1.94) | 0.002 | |||
| sTNFR2, per ng/mla | 3.27 (1.65-6.47) | 0.001 | 3.21 (1.61-6.39) | 0.001 | 3.20 (1.62-6.29) | 0.001 | 3.16 (1.59-6.25) | 0.001 | |||
| Lipocalin 2, per ng/ml | 1.23 (0.79-1.93) | 0.363 | 1.21 (0.77-1.90) | 0.401 | 1.23 (0.78-1.93) | 0.367 | 1.22 (0.77-1.91) | 0.397 | |||
a Log-transformed before analysis; b Base Model adjusted for age, sex and smoking status.