Table 2. Number of surviving animals following treatment with BocNHO and CBI-indole2.
Day | BocNHO | CBI-indole2 | Vehicle |
---|---|---|---|
0 |
9 |
9 |
10 |
11 |
8 |
7 |
10 |
20 |
7 |
0 |
10 |
32 | 7 | 0 | 9 |
Following treatment of lung-tumor-burdened mice with BocNHO or CBI-indole2, increased survival was observed in the 60 µg/kg BocNHO and vehicle treatment groups compared with 60 µg/kg CBI-indole2, suggesting reduced toxicity of the BocNHO prodrug (Fig. 6A).