Figure 5. Spatial memory and choice performance on the spatial-discrimination beacon water maze task in IL-1R1^−/− and WT mice.

IL-1R1^−/− and WT mice (n = 10) were trained (8 trials per day for 12 days) to discriminate between two identical beacons (diameter 15 cm; 24 cm high, sitting on the water surface) depending on their spatial locations, one of which had a hidden platform underneath. 1 block = 24 trials. a) First choice accuracy to choose the correct beacon was assessed. b) Probe test performed after 72 trials, with 25% depicted by dotted line. The percentage correct choices on choosing the correct beacon are shown when start position is c) close to correct beacon, d) equal distance from both beacons and e) furthest from correct beacon. * p<0.05 by one-tailed t-test comparison of first choice accuracy across all trials. Data are expressed as mean±SEM and full statistical analysis is described in the text.