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. 2013 Oct 30;8(10):e78344. doi: 10.1371/journal.pone.0078344

Figure 5. miR-200c inhibited angiogenesis of endothelial cells.

Figure 5

HUVECs were transfected with miR-200c mimics, miR-200c inhibitors or si-VEGFR2. (A) HUVECs were cultured on Matrigel 48 h after transfection. Representative images of capillary-like structures formed and (B) the length of capillary structure were quantified. (C) The transfected HUVECs were also seeded onto the upper chamber of 8.0-mm pore size 24-well transwell plates to investigate cell migration ability. (D) The migratory cells were counted and statistically analyzed. Each experiment was repeated three times. Standard errors of the mean are shown by error bars. *indicates p<0.05 compared to the control.