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. 2013 Aug 23;6(5):1343–1345. doi: 10.3892/ol.2013.1544

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Copyright © 2013, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Image of the CTC-KRAS mutational status for patient CR6. The CD45⁺ cell fraction (mainly leukocytes) provides a positive signal for the control assay corresponding to KRAS exon-4. The CD45⁻/CD326⁻ cell fraction exhibits a positive signal of the control assay corresponding to KRAS exon-4. The CD45⁻/CD326⁺ cell fraction exhibits a positive signal of the control assay corresponding to KRAS exon-4 and a signal for the KRAS-12Ala mutation. CTC, circulating tumour cell.