Skip to main content
. 2013 Oct 30;8(10):e76251. doi: 10.1371/journal.pone.0076251

Table 4. Chromosomes 18, 20,7 and 8 loss and gain.

Cytoband CRC Gene Other Gene G-score Function
18q22.3 TSHZ1 2.658 Encodes a colon cancer antigen, involved in transcriptional regulation
18q21 DCC 2.399 Tumor suppressor gene in colon carcinogenesis
18q21.33 BCL2 2.365 Regulation of apoptosis
18q21.32 MALT1 2.326 Tumor Suppression.
18q21.31 ATP8B1 2.326 Aminophospholipid Transporter
18q21 NARS 2.326 Asparaginyl-tRNA synthetase
18q21.1 SMAD2 2.259 Transcription factors and gene regulation
18q21.1 ATP5A1 2.259 Tumor suppressor, regulation of apoptosis
18q21 SMAD7 2.259 Transcription factors and gene regulation
18q21.2 SMAD4 2.259 Transcription factors and gene regulation
20q13.2 BCAS1 5.323 Oncogene, aggressive tumors.
20q13.31 CTCFL 4.836 Gene regulation, oncogene in ovarian cancer
20q13.31 SPO11 4.8360 Gene binding, ATP binding
20q13.3 GNAS 4.781 Oncogene
20q13 AURKA 4.722 Oncogene, tumor development
20q13.1 DPM1 4.662 Transferase activity
20q13.2 ZNF217 4.662 Role in breast cancer
7p21 PLEKHA8 2.018 Intracellular trafficking
7p15.2 HOXA3 2.000 Transcription factor
7p15.3 GPNMB 2.000 Role in metastasis
7p15.3 IGF2BP3 2.000 Binding protein
7p21 IL6 2.00 Tumor progression
7p15 INHBA 1.944 Cell Signaling
8q24.21 PCAT1 3.420 Non-protein coding prostate cancer transcript

Chromosome 18 has the steepest copy number loss (53.33%), chromosome 20 the maximum copy number gain (80%), chromosome 7 has a high gain (60%) and ranks second to chromosome 20 in terms of copy gain.

BCAS1 in chr20 has the highest G-score overall. Genes in CRC and in other cancers are identified based on the cytoband coordinates for the aberrated regions. Seven genes out of ten were involved in CRC and other three have role in various cancers in chromosome 18. G-scores indicate critical regions to drive cancer by accounting for the false discovery rate corrected significance of the frequency of gain and the average copy number for samples with gain at each probe position. TSHZ1 at the 18q22.3 shows highest G-Score value of 2.658 for observations on that chromosome with an associated copy number loss of 53.33%.