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Inhibition of PI3K activity blocks colony formation in A2780/PTX cells. (A) Representative images and (B) summary data showing the effect of the PI3K inhibitor, LY294002 (10 μM). Images of the cells were captured after 14 days (upper panels in A). Tumor spheres formed from 2,000 A2780/PTX cells, with and without LY294002 treatment (lower panels in A). Control indicates DMSO (0.1%). *P<0.05, compared with A2780/PTX cells without LY294002. DMSO, dimethyl sulfoxide.
