Table 1. Fetal anthropometric measurements following Sildenafil citrate (SC) treatment.
WATER (N = 14 litters) | SC TREATED (N = 11 litters) | ||||
WT (n = 56) | P0 (n = 53) | WT (n = 46) | P0 (n = 49) | ||
Crown:rump length (mm) | Genotype***Treatment NS | 28.9±0.3 | 26.6±0.3 | 29.1±0.4 | 27.1±0.3 |
Abdominal circ (mm) | Genotype*** Treatment** | 26.3±0.3 | 23.1±0.4 | 27.2±0.3a | 24.3±0.5b |
Head circ (mm) | Genotype* Treatment NS | 24.8±0.2 | 24.1±0.2 | 24.8±0.1 | 24.6±0.1 |
Crown:rump length, abdominal and head circumference of WT and P0 fetuses at E18.5 from untreated water (control) and SC treated dams. Mean ± SEM. Statistical analyses were performed by Generalized Linear Mixed Models test followed by Sequential Sidak multiple comparison test. This assessed effects of genotype and treatment.
P<0.05,
P<0.01,
P<0.001.
P<0.01 versus WT control;
P<0.01 versus P0 control.