Figure 2.

In vivo analysis of hLATS1/2 and mutants for their ability to rescue the lethality induced by loss of the endogenous wts gene function. Relative survival rate is measured by the number of adult females divided by the number of adult males produced by parental flies of males MS1096-Gal4 (on the X chromosome) crossed with females with genotype as indicated. The number of offspring males serves as a control to estimate an expected number of female flies that express the UAS transgenes driven by MS1096-Gal4. In a wts-RNAi (II) background, the survival rate in the absence of LATS transgenic expression was zero (the control column). Between 40 and 148 offspring males were scored from each cross.