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. 2013 Oct 31;7:200. doi: 10.3389/fncel.2013.00200

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Copyright © 2013 Smidt and van Hooft.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular identity of 5-HT neuronal subgroups. (A) Definition of broads programs of 5-HT neuronal specification. (B) The general pool of 5-HT neurons is molecularly divided in a rostral and caudal subgroup. These subgroups are identified by the presence of Hmx/Gata2 and Hox/Gata3 genes. The most rostral group can be subdivided by the presence or absence of the homeodomain genes Engrailed 1 and 2 (En1/2). (C) Next to the position related programming differences (B) more disperse transcription factors dependence (Pet1) and 5-HT subset markers exist in the 5-HT neuronal cluster.