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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Curr Opin Biotechnol. 2013 Aug 2;24(5):10.1016/j.copbio.2013.07.003. doi: 10.1016/j.copbio.2013.07.003

Figure 2. Mechanical factors may influence tenogenic differentiation of mesenchymal stem cells.

Figure 2

The tenogenic effect of dynamic tensile strain may be mediated through FAK, RhoA/ROCK and the actin cytoskeleton in MSCs. While tension is tenogenic, compressive loading may induce a fibrocartilage-like phenotype. Substrate stiffness may provide an additional mechanical signal to influence stem cell tenogenesis.