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. 2013 Oct 31;3:3100. doi: 10.1038/srep03100

Figure 1. Avoidance of a chamber filled with chemical vapor.

Figure 1

(a) Homemade testing apparatus for avoidance/preference behavior. (b, c) WT mice (n = 6) never entered the chamber with formalin (100 ppm) while TRPA1 KO mice (n = 6) entered without hesitation. Numbers at bottom of columns indicate absolute values averaged by group and used in ratio calculations. (d) Dose-response relationship of WT mice (n = 5 per dose) to enter the formalin chamber. (e) Nasal (n = 10 for both vehicle and blocker) but not subcutaneous (n = 6) administration of AP18 blocked avoidance to 50 ppm formalin in WT mice. (f) Similar abnormality in KO mice was observed when formalin was replaced by other TRPA1 agonists allyl isothiocyanate or acrolein (n = 6 per group). Error bars indicate s.e.m.