Figure 10.
In vivo neutralization of MCP-1 significantly reduces parenchymal infiltration after T cell transfer. Histologic sections from lungs harvested 4 days after adoptive transfer of 2.5 × 106 CD8+ T cell clone 40-2 with coadministration of Ab in the tail vein. (a) The infiltration of lung parenchyma harvested from an SPC-HA–transgenic mouse 96 hours after transfer of T cells with control Ab. (b) The typical pattern of infiltration in the SPC-HA–transgenic animals that received Ab to MCP-1 at the time of T cell transfer (50 μg/animal). The cellular infiltrates are significantly reduced, and the residual infiltrates are nearly devoid of macrophages by immunohistochemistry (not shown).