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. 2000 Sep 15;106(6):R49–R58. doi: 10.1172/JCI9786

Figure 8.

Figure 8

MCP-1 protein production by alveolar cells is triggered by CD8+ T cell recognition, and induction is mediated by TNF-α. ELISAs were performed on supernatants of combined cultures at varying times in the presence (filled and hatched bars) or absence (open bars) of 10–8 M peptide. Hatched bars indicate wells in which Ab to TNF-α was added. MCP-1 protein expression was detectable by 4 hours and was significantly induced after 6 hours of incubation of MLE-Kd cells with CD8+ T cells and peptide. Protein production was inhibited by anti–TNF-α. AP < 0.05, BP < 0.01 compared with the level with anti-TNF.