Table 2. The extent of infiltration of peripheral organs by lymphocytes in mice that developed thymic lymphomas following exposure to MNU. An asterisk indicates sacrifice of the animal at the end of the study (20 weeks).
| Genotype | Mouse | Time of tumour onset | Lung | Liver | Kidney | Spleen |
|---|---|---|---|---|---|---|
| wild type | 458 | 128 | Y | Y | Y | Y |
| 483 | 100 | - | - | - | - | |
| 497 | 140* | Y | - | - | - | |
| 527 | 72 | Y | Y | Y | Y | |
| 555 | 140* | Y | Y | Y | Y | |
| 600 | 140* | - | - | - | - | |
| 616 | 140* | Y | - | Y | - | |
| 619 | 140* | Y | Y | Y | Y | |
| 670 | 109 | Y | Y | Y | Y | |
| p53312A/A | 467 | 115 | - | Y | - | Y |
| 470 | 116 | Y | Y | Y | Y | |
| 489 | 108 | Y | Y | Y | Y | |
| 511 | 85 | Y | - | - | - | |
| 520 | 97 | - | - | - | Y | |
| 537 | 131 | Y | Y | Y | Y | |
| 584 | 74 | Y | Y | Y | - | |
| E2F1−/− | 479 | 80 | Y | Y | Y | Y |
| 545 | 111 | - | - | - | - | |
| 562 | 140* | - | - | - | - | |
| 590 | 140* | Y | Y | Y | Y | |
| p53312A/A; E2F1−/− | 456 | 137 | - | - | - | - |
| 506 | 102 | Y | Y | Y | Y | |
| 521 | 75 | Y | Y | Y | Y | |
| 567 | 140* | Y | - | - | Y | |
| 575 | 111 | Y | Y | Y | Y | |
| 580 | 124 | Y | Y | Y | Y | |
| 663 | 85 | - | - | Y | - |